It's a pain in the @$$, since you have to purchase two different sized wheels. And if you like to rotate them regularly, like me, the only rotation you can do w/ the 100mm wheels are the 2nd position of both skates. This changes with a 2&2 setup (110-100-100-110).
Their pros are a slightly (maybe 1-2mm, depending on the frame) lower deck height and a slightly smaller overall length.
As for noticeable differences, I noticed a slightly better roll with the 4x110mm setups than with a hi-lo.
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Indoor Inline: Pinnacle Full Customs | Simmons SR110 4x110 | TLTF/Simmons | NMB
Outdoor Inline: Simmons Full Customs | Simmons SR110 4x110 | Junk Wheels | NMB
Quads: Reidell 911 | Roll-Line Mistral | Corey Super-Ds/JG Hubs | Bones Swiss
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